2020-12-31 12:55:20 UTC
The research is hard to ignore, vaccines can trigger autoimmunity with a
laundry list of diseases to follow. With harmful and toxic metals as some
vaccine ingredients, who is susceptible and which individuals are more at
No one would accuse Yehuda Shoenfeld of being a quack. The Israeli clinician
has spent more than three decades studying the human immune system and is at
the pinnacle of his profession. You might say he is more foundation than
fringe in his specialty; he wrote the textbooks. The Mosaic of Autoimmunity,
Autoantibodies, Diagnostic Criteria in Autoimmune Diseases, Infection and
Autoimmunity, Cancer and Autoimmunity – the list is 25 titles long and some
of them are cornerstones of clinical practice. Hardly surprising that
Shoenfeld has been called the "Godfather of Autoimmunology" – the study of
the immune system turned on itself in a wide array of diseases from type 1
diabetes to ulcerative colitis and multiple sclerosis.
But something strange is happening in the world of immunology lately and a
small evidence of it is that the Godfather of Autoimmunology is pointing to
vaccines – specifically, some of their ingredients including the toxic metal
aluminum – as a significant contributor to the growing global epidemic of
autoimmune diseases. The bigger evidence is a huge body of research that's
poured in in the past 15 years, and particularly in the past five years.
Take for example, a recent article published in the journal Pharmacological
Research in which Shoenfeld and colleagues issue unprecedented guidelines
naming four categories of people who are most at risk for vaccine-induced
"On one hand," vaccines prevent infections which can trigger autoimmunity,
say the paper's authors, Alessandra Soriano, of the Department of Clinical
Medicine and Rheumatology at the Campus Bio-Medico University in Rome,
Gideon Nesher, of the Hebrew University Medical School in Jerusalem and
Shoenfeld, founder and head of the Zabludowicz Center of Autoimmune Diseases
in the Sheba Medical Center at Tel Hashomer. He is also editor of three
medical journals and author of more than 1,500 research papers across the
spectrum of medical journalism and founder of the International Congress on
Autoimmunology. "On the other hand, many reports that describe
post-vaccination autoimmunity strongly suggest that vaccines can indeed
trigger autoimmunity. Defined autoimmune diseases that may occur following
vaccinations include arthritis, lupus (systemic lupus erythematosus, SLE)
diabetes mellitus, thrombocytopenia, vasculitis, dermatomyosiositis,
Guillain-Barre syndrome and demyelinating disorders. Almost all types of
vaccines have been reported to be associated with the onset of ASIA."
ASIA – or Autoimmune/inflammatory Syndrome Induced by Adjuvants (also known
as Shoenfeld's syndrome) -- first appeared in the Journal of Autoimmunology
four years ago. It is an umbrella term for a collection of similar symptoms,
including Chronic Fatigue Syndrome, that result after exposure to an
adjuvant – an environmental agent including common vaccine ingredients that
stimulate the immune system. Since then an enormous body of research, using
ASIA as a paradigm, has begun to unravel the mystery of how environmental
toxins, particularly the metal aluminum used in vaccines, can trigger an
immune system chain reaction in susceptible individuals and may lead to
overt autoimmune disease.
Autoimmune disease results when the body's system meant to attack foreign
invaders turns instead to attack part of the body it belongs to (auto is
Greek for self). If the immune system is like a national defence system,
antibodies are like drones programmed to recognize a certain type of invader
(a bacteria say) and to destroy them or mark them for destruction by other
special forces. Autoantibodies are like drones that are misidentifying a
component of the human body and have launched a sustained attack on it. If
they mistakenly target a component of the conductive sheath around neurons,
for example, nerve impulses stop conducting properly, muscles go into spasm
and coordination fails; multiple sclerosis results. If autoantibodies
erroneously focus on joint tissue; rheumatoid arthritis results. If they
target the islets of Langerhans in the pancreas, Type 1 diabetes, and so on
"Throughout our lifetime the normal immune system walks a fine line between
preserving normal immune reactions and developing autoimmune diseases," says
the paper. "The healthy immune system is tolerant to self-antigens. When
self-tolerance is disturbed, dysregulation of the immune system follows,
resulting in emergence of an autoimmune disease. Vaccination is one of the
conditions that may disturb this homeostasis in susceptible individuals,
resulting in autoimmune phenomena and ASIA."
Who is "susceptible" is the subject of the paper entitled, "Predicting
post-vaccination autoimmunity: Who might be at risk?" It lists four
categories of people: 1) those who have had a previous autoimmune reaction
to a vaccine, 2) anyone with a medical history of autoimmunity, 3) patients
with a history of allergic reactions, 4) anyone at high risk of developing
autoimmune disease including anyone with a family history of autoimmunity,
presence of autoantibodies which are detectable by blood tests and other
factors including low vitamin D and smoking.
Regarding those who have had a previous adverse reaction to vaccines, the
paper cites five relevant studies including the case of a death of a teenage
girl six months following her third Gardasil injection against HPV virus.
She had experienced a range of symptoms shortly after her first dose,
including dizziness, numbness and tingling in her hands, and memory lapses.
After her second injection, she developed "intermittent arm weakness,
frequent tiredness requiring daytime naps," worse tingling, night sweats,
chest pain and palpitations. A full autopsy was unrevealing but blood and
spleen tissue analysis revealed HPV-16 L1 gene DNA fragments – matching the
DNA found in vials of the Gardasil vaccine against cervical cancer – "thus
implicating the vaccine as a causal factor." The DNA fragments had also been
found to be "complexed with the aluminum adjuvant" which, according to the
report, have been shown to persist for up to 8 to 10 years causing chronic
immune system stimulation.
"Although data is limited," Shoenfeld and his colleagues concluded, "it
seems preferable that individuals with prior autoimmune or autoimmune-like
reactions to vaccinations, should not be immunized, at least not with the
same type of vaccine."
ESTABLISHED AUTOIMMUNE CONDITION
The second group which the paper cites for vaccine exemption is patients
with "established autoimmune conditions." Vaccines don't work so well in
them, say Shoenfeld and his colleagues, and they are at "risk for flares
following vaccination." Inoculations that contain live viruses including
chickenpox, yellow fever and the measles, mumps and rubella triple vaccine
(MMR) are "generally contraindicated" for people with autoimmune conditions
because of the risk of "uncontrolled viral replication." But inactivated
vaccines are not such a good idea either because they usually contain the
added ingredient aluminum, linked to autoimmunity.
The immunologists describe recent studies in which patients with autoimmune
rheumatic disease given the influenza vaccine (without aluminum) suffered
more joint pain and fever than controls and whose levels of autoantibodies
(the drones that attack self) increased after receiving the flu vaccine.
What's more, they developed new types of autoantibodies that weren't present
before the vaccines, and those persisted. As the presence of autoantibodies
can be predictive of developing autoimmune disease in patients without
symptoms, even years ahead of disease onset, this is troubling to those who
A number of studies claim vaccines are safe for the "overwhelming majority
of patients with established autoimmune diseases," the study allows, but
they only looked at rheumatoid arthritis and lupus and not at severe and
active cases so "the potential benefit of vaccination should be weighed
against its potential risk," they cautioned.
PATIENTS WITH A HISTORY OF ALLERGY
Vaccine trials have usually excluded "vulnerable" individuals -- only
extremely healthy individuals with no allergies are recruited. It's a
"selection bias," say Soriano and Shoenfeld, and has likely resulted in
serious adverse events being "considerably underestimated" in "real life
where vaccines are mandated to all individuals regardless of their
susceptibility." The true incidence of allergic reactions to vaccines,
normally estimated at between one in 50,000 to one in a million doses, is
probably much higher and particularly where gelatin or egg proteins are on
the ingredients list, they say.
There's a long list of vaccine ingredients that are potential allergens:
besides the infectious agents themselves, there are those from hen's egg,
horse serum, baker's yeast, numerous antibiotics, formaldehyde and lactose,
as well "inadvertent" ingredients such as latex. People's allergic histories
have to be taken before vaccination say the researchers. But some signs of
reaction don't show up until after the shot.
The public health nurse or GP might tell patients that a long-lasting
swelling around the injection site after a vaccine is a normal reaction, for
example. But that is not what the immunologists say. "[A]luminum
sensitization manifests as nodules [hard lumps] at the injection site that
often regress after weeks or months, but may persist for years." In such
cases, they say, a patch test can be done to confirm sensitivity and to
According to a growing body of research, though, allergy may be only the
beginning of many dangerous aluminum-induced phenomena.
THE TROUBLE WITH ALUMINUM
Aluminum has been added to vaccines since about 1926 when Alexander Glenny
and colleagues noticed it would produce better antibody responses in
vaccines than the antigen alone. Glenny figured the alum was inducing what
he called a "depot effect" – slowing the release of the antigen and
heightening the immune response. For 60 years his theory was accepted dogma.
And over the same time, the vaccine schedule grew decade on decade, but few
ever questioned the effects of injecting aluminum into the body, which is
strange considering its known toxicity.
A PubMed search on aluminum and "toxicity" turns up 4,258 entries. Its
neurotoxicity is well documented. It affects memory, cognition, psychomotor
control; it damages the blood brain barrier, activates brain inflammation,
depresses mitochondrial function and plenty of research suggests it is a key
player in the formation of the amyloid "plaques" and tangles in the brains
of Alzheimer's patients. It's been implicated in Amyotrophic Lateral
Sclerosis and autism and demonstrated to induce allergy.
When kidney dialysis patients were accidentally infused with aluminum, the
"dialysis-induced encephalopathy" (DAE) they developed neurological
symptoms: speech abnormalities, tremors, memory loss, impaired concentration
and behavioural changes. Many of the patients eventually went into comas and
died. The lucky ones survived: when the source of toxicity, aluminum, was
removed from their dialysis they recovered rapidly.
With these new observations, researchers began investigating the adjuvant
effects of aluminum and in the past decade there has been a flurry of
research. Far from being a sandbag that holds the antigen for a while and
then gets excreted, it turns out that aluminum salts trigger a storm of
defence action. Within hours of injection of the same aluminum oxyhydroxide
in vaccines into mice, for example, armies of specialized immune cells are
on the move, calling in grid coordinates for more specialist assault forces.
Within a day, a whole host of immune system commandos are in play --
neutrophils, eosinophils, inflammatory monocytes, myeloid and dendritic
cells, activating lymphocytes and secreting proteins called cytokines. The
cytokines themselves cause collateral damage but they send out signals,
directing cell-to-cell communication and recruiting other cells into action.
If the next phase of the attack is launched: fibroblast growth factor,
interferons, interleukins, platelet derived growth factor, transforming
growth factor and tumour necrosis factor might all be engaged. There's
evidence that poorly understood and pesky inflammasomes, (currently a topic
of cutting- edge cancer causation research) such as the Nod-like receptor
3( NLRP) are activated too, but it's all still too early to say exactly what
New research emerging from University of British Columbia has found that
aluminum adjuvant injected into mice can alter the expression of genes
associated with autoimmunity. And in their recent study published in the
Proceedings of the National Academy of Sciences, immunologists at the
University of Colorado found that even host DNA is recruited into the
aluminum assault, that it rapidly coats injected alum, triggering effects
that scientists have barely scratched the surface of understanding.
THE SIGNIFICANCE OF MACROPHAGIC MYOFASCIITIS
This mobility or "translocation" of aluminum in the body is perhaps the most
disturbing of the mounting evidence in current aluminum research. In 1998,
French researcher Romain Gherardi and his colleagues observed an emerging
condition of unknown origin which presented in patients post-vaccination
with Chronic Fatigue like symptoms including swollen lymph nodes, joint and
muscle pain and exhaustion. Tissue biopsies of the patients' deltoid
revealed lesions up to 1 cm in diameter and unique from similar lesions of
other diseases. They went to the lab for analysis and to Gherardi's
astonishment, they mainly consisted of macrophages – large white blood cells
in the immune system whose job is to swallow up foreign invaders in the
body. Enclosed in the cellular fluid of these phagocytes were agglomerates
of nanocrystals of aluminum.
Gherardi and his colleagues began injecting mice with aluminum to see what
happened. Their research published in 2013 revealed that the metal particles
were engulfed by macrophages and formed MMF-like granulomas that
dispersed -- to distant lymph nodes, spleen, liver and eventually brain.
"This strongly suggests that long-term adjuvant biopersistence within
phagocytic cells is a prerequisite of slow brain translocation and delayed
neurotoxicity," writes Gherardi in his February 2015 review of the relevant
research in Frontiers in Neurology.
A more frightening animal study of aluminum is that of Spanish veterinary
researcher Lluis Lujan's study of ovine ASIA. After huge numbers of sheep in
Spain died in 2008 in the wake of a compulsory multiple vaccine campaign
against bluetongue in Spain in 2008, Lujan set out to find out what killed
them – and he began by inoculating them with aluminum.
His 2013 study found that only 0.5% of sheep inoculated with aluminum
vaccines showed immediate reactions of lethargy, transient blindness,
stupor, prostration and seizures – "characterized by a severe
meningoencephalitis, similar to postvaccine reactions seen in humans." Most
of them recovered, temporarily, but postmortem exams of the ones who didn't
revealed acute brain inflammation.
The delayed onset "chronic" phase of the disease affected far more of the
sheep -- 50-70% of flocks and sometimes virtually 100% of animals within a
given flock, usually including all of those who had previously recovered.
The reaction was frequently triggered by exposure to cold and began with
restlessness and compulsive wool-biting, then progressed to acute redness of
the skin, generalized weakness, extreme weight loss and muscle tremors, and
finally, entered the terminal phase where the animals went down on their
front quarters, became comatose and died. Post-mortem examinations revealed
"severe neuron necrosis" and aluminum in the nerve tissue.
The immune system's reaction to aluminum "represents a major health
challenge," Gerhardi declares in his recent review, and he adds that
"attempts to seriously examine safety concerns raised by the bio-persistent
character and brain accumulation of alum particles have not been made... A
lot must be done to understand how, in certain individuals, alum-containing
vaccines may become insidiously unsafe."
Back to the problem of which "certain individuals" should avoid vaccination
to avoid autoimmune disease.